Integrins and Actions of Androgen in Breast Cancer
Chung‐Che Tsai, Yu‐Chen S. H. Yang, Yi‐Fong Chen, Linyi Huang, Yung‐Ning Yang, Sheng‐Yang Lee, Wenlong Wang, Hsin‐Lun Lee, Jacqueline Whang‐Peng, Hung‐Yun Lin, Kuan Wang
Abstract
Androgen has been shown to regulate male physiological activities and cancer proliferation. It is used to antagonize estrogen-induced proliferative effects in breast cancer cells. However, evidence indicates that androgen can stimulate cancer cell growth in estrogen receptor (ER)-positive and ER-negative breast cancer cells via different types of receptors and different mechanisms. Androgen-induced cancer growth and metastasis link with different types of integrins. Integrin αvβ3 is predominantly expressed and activated in cancer cells and rapidly dividing endothelial cells. Programmed death-ligand 1 (PD-L1) also plays a vital role in cancer growth. The part of integrins in action with androgen in cancer cells is not fully mechanically understood. To clarify the interactions between androgen and integrin αvβ3, we carried out molecular modeling to explain the potential interactions of androgen with integrin αvβ3. The androgen-regulated mechanisms on PD-L1 and its effects were also addressed.