Mitochondrial C1qbp promotes differentiation of effector CD8 <sup>+</sup> T cells via metabolic-epigenetic reprogramming
Xingyuan Zhai, Kai Liu, Hongkun Fang, Quan Zhang, Xianjun Gao, Fang Liu, Shangshang Zhou, Xinming Wang, Yujia Niu, Yazhen Hong, Shuhai Lin, Wen‐Hsien Liu, Changchun Xiao, Qiyuan Li, Nengming Xiao
Abstract
C1qbp promotes epigenetic and transcriptional regulation of effector CD8 + T cell differentiation through up-regulation of OXPHOS.
Topics & Concepts
EffectorBiologyCell biologyCytotoxic T cellOxidative phosphorylationCellular differentiationCD8ChemistryImmune systemBiochemistryImmunologyGeneIn vitroImmune Cell Function and InteractionImmune cells in cancerT-cell and B-cell Immunology