Organocatalytic Enantioselective Construction of Heterocycle-Substituted Styrenes with Chiral Atropisomerism
Quan‐Zhe Li, Peng-Fei Lian, Fu-Xin Tan, Guo-Dong Zhu, Chao Chen, Hao Yu, Wei Jiang, Xun-Hui Wang, Jia Zhou, Shu‐Yu Zhang
Abstract
-alkynyl-naphthylamines as the electrophile, indoles and 4-hydroxycoumarins were efficiently employed to construct axially chiral skeletons in good yields and with excellent enantioselectivities (up to 97% enantiomeric excess). Furthermore, the resulting products could be converted to potential squaramides featuring organic catalysts.
Topics & Concepts
AtropisomerEnantioselective synthesisChemistryOrganocatalysisCombinatorial chemistryCatalysisOrganic chemistryStereochemistryAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityBiological Activity of Diterpenoids and Biflavonoids