Antibacterial infection and immune-evasive coating for orthopedic implants
Kyomin Chae, Woo Young Jang, Kijun Park, Jinhyeok Lee, Hyunchul Kim, Kyoungbun Lee, Chang Kyu Lee, Yeontaek Lee, Soon Hyuck Lee, Jungmok Seo
Abstract
pitcher plant. LOIS presents a long-lasting, extreme liquid repellency against diverse liquids and biosubstances including cells, proteins, calcium, and bacteria. In addition, we confirmed mechanical durability against scratches and fixation force by simulating inevitable damages during surgical procedure ex vivo. The antibiofouling and anti-infection capability of LOIS were thoroughly investigated using an osteomyelitis femoral fracture model of rabbits. We envision that the LOIS with antibiofouling properties and mechanical durability is a step forward in infection-free orthopedic surgeries.
Topics & Concepts
Immune systemOrthopedic surgeryCoatingMedicineImmunologyBiologyMicrobiologyMaterials scienceNanotechnologySurgeryOrthopedic Infections and TreatmentsPolymer Surface Interaction StudiesBone Tissue Engineering Materials