Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients
Zheng Zhou, Jiasheng Cao, Xiaoming Liu, Mingsong Li
Abstract
UC, Ulcerative colitis; IBD, Inflammatory bowel disease; DEGs, Differentially expressed genes; GEO, Gene Expression Omnibus; SVA, Spatial variant apodization; LIMMA, Linear models for the microarray data; FC, Fold change; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; GSVA, Gene Set Variation Analysis; MSigDB, Molecular Signatures Database; WT, Wild-type; DSS, Dextran sulfate sodium; HC, Healthy control; SD, Standard deviation; SNHG5, Small nucleolar RNA host gene 5; GLP-2, Glucagon-like peptide 2; GSE, Gene set enrichment; ECM, Extracellular matrix; TCA, Tricarboxylic acid cycle; NA, Not available.
Topics & Concepts
ButyrateUlcerative colitisCitrobacter rodentiumKEGGColitisGeneInflammatory bowel diseaseGene expressionBiologyCancer researchImmunologyDiseaseMedicineGene ontologyInternal medicineGeneticsBiochemistryFermentationInflammatory Bowel DiseaseMicroRNA in disease regulationCancer-related molecular mechanisms research