Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
Pierpaolo Risiglione, Federica Zinghirino, Maria Carmela Di Rosa, Andrea Magrì, Angela Messina
Abstract
Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including αSyn. This review analyzes the main aspects of αSyn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.
Topics & Concepts
Voltage-dependent anion channelMitochondrionCell biologyOrganelleCytosolMitophagyAlpha-synucleinBiologyFunction (biology)NeuroscienceBacterial outer membraneParkinson's diseaseBiochemistryAutophagyDiseaseMedicineApoptosisPathologyEnzymeGeneEscherichia coliMitochondrial Function and PathologyParkinson's Disease Mechanisms and TreatmentsGenetic Neurodegenerative Diseases