Antibacterial Pentacyclic Polyketides from a Soil-Derived <i>Streptomyces</i>
Jie Yuan, Li Wang, Jinqiu Ren, Jianping Huang, Mingming Yu, Jun Tang, Yijun Yan, Jing Yang, Sheng‐Xiong Huang
Abstract
Nine new pentacyclic polyketides, fasamycins G–K (1–5) and formicamycins N–Q (6–9), along with 10 known analogues (10–19), were isolated from a rhizospheric soil-derived Streptomyces sp. KIB-1414. Their structures and absolute configurations were elucidated by interpretation of NMR and HRMS data and comparisons of CD data. The compounds were active against methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Bacillus subtilis, and Escherichia coli strains, with MIC values ranging from 0.20 to 50.00 μg/mL.
Topics & Concepts
Staphylococcus aureusBacillus subtilisStreptomycesStereochemistryAntibacterial activityEscherichia coliMicrobiologyAntibacterial agentBiologyChemistryBacteriaAntibioticsBiochemistryGeneticsGeneMicrobial Natural Products and BiosynthesisPlant-Microbe Interactions and ImmunityPlant Disease Resistance and Genetics