Latent Tuberculosis Infection Diagnosis among Household Contacts in a High Tuberculosis-Burden Area: a Comparison between Transcript Signature and Interferon Gamma Release Assay
Sheetal Kaul, Vivek Nair, Shweta Birla, Shikha Dhawan, Sumit Rathore, Vishal Khanna, Sheelu Lohiya, Shakir Ali, Shamim Mannan, Kiran Rade, Pawan Malhotra, Dinesh Gupta, Ashwani Khanna, Asif Mohmmed
Abstract
The study compares potential of transcript signature and IGRA to diagnose LTBI. It is first of its kind study to screen household contacts (HHCs) in high TB burden area of India. A transcript signature ( FCGR1B, GBP1 , & GBP5 ) is identified as potential biomarker for LTBI. These results can lead to development of point-of-care (POC) like device for LTBI screening in a high TB burdened area.
Topics & Concepts
TuberculosisLatent tuberculosisInterferon gammaMedicineInterferon γVirologyImmunologyInterferon gamma release assayBiologyMycobacterium tuberculosisDemographyPathologyCytokineSociologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisPneumonia and Respiratory Infections