An overview on synthesis and biological activity of pyrimidines
Mosaad S. Mohamed, Samir M. Awad, Neama Abdallah Abd El-tawab, Naglaa Mohamed Ahmed
Abstract
Pyrimidines represent an important class of heterocycles containing two nitrogen atoms at position 1 and 3 of the six membered ring show wide range of biological activities. Numerous methods for the synthesis of pyrimidine and their diverse reactions offer enormous scope in the field of medicinal chemistry. Pyrimidine possesses wide spectrum of biological activities including antitubercular, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, anticancer, and anti-HIV activity. The present review attempts to give brief information about the synthesis and various biological activities of pyrimidines and their derivatives.
Topics & Concepts
PyrimidineAntifungalBroad spectrumCombinatorial chemistryHuman immunodeficiency virus (HIV)Biological activityChemistryScope (computer science)Ring (chemistry)StereochemistryBiologyBiochemistryComputer scienceOrganic chemistryMicrobiologyIn vitroVirologyProgramming languageSynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis of heterocyclic compounds