The ERα-miR-575-p27 feedback loop regulates tamoxifen sensitivity in ER-positive Breast Cancer
Shu-Shu Liu, Yun Li, Hui Zhang, Di Zhang, Xiaobei Zhang, Xin Wang, Yue Yu
Abstract
Our data reveal the ERα-miR-575-CDKN1B feedback loop in ER+ breast cancer, suggesting that miR-575 can be used as a prognostic biomarker in patients with ER+ breast cancer, as well as a predictor or a promising target for tamoxifen sensitivity.
Topics & Concepts
TamoxifenBreast cancerPositive feedbackFeedback loopSensitivity (control systems)Estrogen receptorCancer researchNegative feedbackInternal medicineOncologyMedicineBiologyCancerChemistryPhysicsComputer scienceElectrical engineeringVoltageQuantum mechanicsEngineeringComputer securityElectronic engineeringMicroRNA in disease regulationCircular RNAs in diseasesRNA Research and Splicing