Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway
Hong Liu, Zhancheng Zhang, Shenli Zhou, Xianfang Liu, Guodong Li, Bing Song, Wei Xu
Topics & Concepts
PI3K/AKT/mTOR pathwayBiologyCancer researchProtein kinase BCancerCell growthCancer cellApoptosisCellCell biologySignal transductionGeneticsCancer, Hypoxia, and MetabolismBarrier Structure and Function StudiesFerroptosis and cancer prognosis