Therapeutic Potential of Prenylated Flavonoids of the Fabaceae Family in Medicinal Chemistry: An Updated Review
Jaime Morante Carriel, Hugo Nájera, Antonio Samper-Herrero, Suzana Živković, María José Martínez‐Esteso, Ascensión Martínez‐Márquez, Susana Sellés‐Marchart, Anna Obrebska, Roque Bru‐Martínez
Abstract
Much attention has been paid to the potential biological activities of prenylated flavonoids (PFs) in various plant families over the last decade. They have enormous potential for biological activities, such as anti-cancer, anti-diabetic, antimicrobial, anti-inflammatory, anti-Alzheimer's, and neuroprotective activities. Medicinal chemists have recently shown a strong interest in PFs, as they are critical to the development of new medicines. PFs have been rapidly prepared by isolation and semi- or full synthesis, demonstrating their significant utility in medicinal chemistry research. This study encompasses the research progress on PFs in the last decade, including their pharmacological activities in the Fabaceae family. This information demonstrates the bioactive potential of PF compounds and their role in the control and treatment of various human health problems.