Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS)
Sebastian Gutsfeld, Leah C. Wehmas, Ifeoluwa Omoyeni, Nicole Schweiger, David Leuthold, Paul Michaelis, Xia Meng Howey, Shaza Gaballah, N. Herold, Carolina Vogs, Carmen R. Wood, Luísa Becker Bertotto, Gi‐Mick Wu, Nils Klüver, Wibke Busch, Stefan Scholz, Jana Schor, Tamara Tal
Abstract
BACKGROUND: Per- and polyfluoroalkyl Substances (PFAS) are synthetic chemicals widely detected in humans and the environment. Exposure to perfluorooctanesulfonic acid (PFOS) or perfluorohexanesulfonic acid (PFHxS) was previously shown to cause dark-phase hyperactivity in larval zebrafish. OBJECTIVES: The objective of this study was to elucidate the mechanism by which PFOS or PFHxS exposure caused hyperactivity in larval zebrafish. METHODS: PFOS or 0.4% DMSO from 1-4 dpf and behavior was assessed at 5 dpf. Coexposure with the ppard antagonist GSK3787 and PFOS was also performed. RESULTS: in PFOS-exposed larvae. DISCUSSION: function. https://doi.org/10.1289/EHP13667.