CO/light dual-activatable Ru(<scp>ii</scp>)-conjugated oligomer agent for lysosome-targeted multimodal cancer therapeutics
Min Yang, Hao Zhao, Ziqi Zhang, Qiong Yuan, Qian Feng, Xinrui Duan, Shu Wang, Yanli Tang
Abstract
the multimodal therapeutics of physical disruption/PDT/chemotherapy. Importantly, Ru-OTE can be directly photo-activated using a two-photon laser (800 nm) for efficient drug release and near-infrared PDT. Furthermore, Ru-OTE with light irradiation inhibits tumor growth in an MDA-MB-231 breast tumor model with negligible side effects. This study demonstrates that the development of an activatable Ru(ii)-conjugated oligomer potential drug provides a new strategy for effective subcellular organelle-targeted multimodal cancer therapeutics.
Topics & Concepts
OligomerLysosomeConjugated systemDual (grammatical number)ChemistryCancer researchMedicineBiochemistryArtPolymer chemistryOrganic chemistryPolymerLiteratureEnzymeNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPorphyrin and Phthalocyanine Chemistry