Iodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-<i>a</i>]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an “On-Water” Platform
Zigmee T. Bhutia, Padmini C. Panjikar, Shruti Iyer, Amrita Chatterjee, Mainak Banerjee
Abstract
]pyridines in good overall yields. Although several of the reactions were efficiently performed "on water", the addition of a surfactant, namely, sodium dodecyl sulphate , was found effective in terms of substrate scope and yield enhancement. Both methods were successfully used for the gram-scale synthesis of a marketed drug, zolimidine. The simple experimental setup, water as "green" media, and inexpensive catalyst are some of the merits of this protocol.
Topics & Concepts
ChemistryCatalysisIodineAqueous mediumArylYield (engineering)Aqueous solutionOrganic chemistryCondensation reactionGreen chemistryCombinatorial chemistryNuclear chemistryIonic liquidMaterials scienceMetallurgyAlkylChemistry and Chemical EngineeringNanomaterials for catalytic reactionsMulticomponent Synthesis of Heterocycles