Design, synthesis and biological evaluation of tetrahydroquinoline-based reversible LSD1 inhibitors
Xinran Wang, Cai Zhang, Xiangyu Zhang, Jiangkun Yan, Jiming Wang, Qinwen Jiang, Liyu Zhao, Dongmei Zhao, Maosheng Cheng
Topics & Concepts
ChemistryIC50EnzymeIn vitroMicrosomeGrowth inhibitionApoptosisDocking (animal)Cell growthStereochemistryNon-competitive inhibitionCombinatorial chemistryBiochemistryMedicineNursingEpigenetics and DNA MethylationEstrogen and related hormone effectsChemical Synthesis and Analysis