HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses
Pavlo A. Nesterenko, Jami McLaughlin, Brandon L. Tsai, Giselle Burton Sojo, Donghui Cheng, Daniel Zhao, Zhiyuan Mao, Nathanael J. Bangayan, Matthew B. Obusan, Yapeng Su, Raymond T. Ng, William Chour, Jingyi Xie, Yan-Ruide Li, Derek Lee, Miyako Noguchi, Camille Carmona, John W. Phillips, Jocelyn T. Kim, Lili Yang, James R. Heath, Paul C. Boutros, Owen N. Witte
Abstract
T cells can recognize evolutionarily diverse coronaviruses. Analysis of individual TCR clones may help define vaccine epitopes that can induce long-term immunity against SARS-CoV-2 and other coronaviruses.
Topics & Concepts
T-cell receptorBiologyVirologyEpitopeCoronavirusT cellCD8Cytotoxic T cellHuman leukocyte antigenAntigenImmunologyGeneticsImmune systemCoronavirus disease 2019 (COVID-19)In vitroInfectious disease (medical specialty)MedicinePathologyDiseaseSARS-CoV-2 and COVID-19 ResearchCAR-T cell therapy researchvaccines and immunoinformatics approaches