Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting
Liting Ren, Wenya Feng, Jie Shao, Juan Ma, Ming Xu, Ben‐Zhan Zhu, Nanfeng Zheng, Sijin Liu
Abstract
These combined data unearthed a remarkably enhanced tumor-killing efficacy of our CuET nanomedicines through nuclear targeting. This work may open a new research area of repurposing DSF as innovative therapeutic agents to treat breast cancer and its metastases.
Topics & Concepts
DisulfiramIn vivoBiodistributionCancer researchPharmacologyChemosensitizerDrugCancerPhotothermal therapyChemistryCancer cellIn vitroMedicineNanotechnologyMaterials scienceCytotoxicityBiologyBiochemistryInternal medicineBiotechnologyNanoplatforms for cancer theranosticsSulfur Compounds in BiologyAutophagy in Disease and Therapy