Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
The University of North Carolina at Chapel Hill University Libraries
Abstract
Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has the potential to identify rare mutations that have a large effect on phenotype.
Topics & Concepts
Internal medicineCardiologyMutationLoss functionCoronary diseaseMedicineFunction (biology)Coronary heart diseaseGeneticsBiologyGenePhenotypePharmacogenetics and Drug MetabolismMitochondrial Function and PathologyReceptor Mechanisms and Signaling