Immune cell β<sub>2</sub>-adrenergic receptors contribute to the development of heart failure
Miles A. Tanner, Charles A. Maitz, Laurel A. Grisanti
Abstract
Immune cell β 2 -adrenergic receptors (β 2 ARs) are important for proinflammatory macrophage infiltration to the heart in a chronic isoproterenol administration model of heart failure. Mice lacking immune cell β 2 AR have decreased immune cell infiltration to their heart, primarily proinflammatory macrophage populations. This decrease culminated to decreased cardiac injury with lessened cardiomyocyte death, decreased interstitial fibrosis and hypertrophy, and improved function demonstrating that β 2 AR regulation of immune responses plays an important role in the heart’s response to persistent βAR stimulation.
Topics & Concepts
Proinflammatory cytokineImmune systemHeart failureReceptorInternal medicineEndocrinologyStimulationMedicineAdrenergic receptorImmunologyBiologyInflammationCardiac Fibrosis and RemodelingReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology