SOX1 Is Required for the Specification of Rostral Hindbrain Neural Progenitor Cells from Human Embryonic Stem Cells
Xinyuan Liu, Zhuoqing Fang, Jing Wen, Fan Tang, Bing Liao, Naihe Jing, Dongmei Lai, Ying Jin
Abstract
-KO-induced aberrant gene expression. Taken together, this study uncovers previously unappreciated role of SOX1 in early neural regionalization and provides new information for the precise control of the OTX2/GBX2 interface.
Topics & Concepts
HindbrainEmbryonic stem cellCell biologyNeural stem cellBiologyProgenitor cellStem cellGeneticsEmbryoGenePluripotent Stem Cells ResearchDevelopmental Biology and Gene RegulationCRISPR and Genetic Engineering