Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells
Yawen Hao, Shaohua Song, Tao Li, Qiuhong Zai, Ningning Ma, Yixin Li, Yang Liu, Peng Xiao, Tianyue Xu, Longshan Ji, Jiaxin Tan, Yeni Ait Ahmed, Xiaogang Xiang, Xiaolin Wang, Fouad Lafdil, Qing Xie, Yonghan He
Abstract
Oxidative stress-driven miR-144 fuels HSC activation and liver fibrogenesis by limiting the SIN3A-p38 axis. Thus, a specific inhibition of miR-144 in HSCs could be a novel therapeutic strategy for the treatment of liver fibrosis.
Topics & Concepts
Hepatic stellate cellOxidative stressmicroRNAHepatic fibrosisCell biologyLiver fibrosisChemistryCancer researchFibrosisBiologyMedicineGeneInternal medicineBiochemistryEndocrinologyLiver Disease Diagnosis and TreatmentLiver physiology and pathologyLiver Disease and Transplantation