Tocopherol controls D1 amino acid oxidation by oxygen radicals in Photosystem II
Aditya Kumar, Ankush Prasad, Michaela Sedlářová, Ravindra Kale, Laurie K. Frankel, Larry Sallans, Terry Bricker, Pavel Pospı́šil
Abstract
Significance During oxygenic photosynthesis Photosystem II is damaged by reactive oxygen species (ROS). It is known that α-tocopherol protects the photosystem from a subset of this oxidative damage. The sites that were protected and the mechanisms leading to protein damage had not been determined. Herein, we identify the ROS responsible for damage on the reducing side of Photosystem II, the protein residues that are damaged by these ROS, and we propose a model localizing α-tocopherol within the photosystem yielding the observed protection.
Topics & Concepts
RadicalPhotosystem IITocopherolChemistryOxygenPhotochemistryAmino acidPhotosynthesisBiochemistryAntioxidantVitamin EOrganic chemistryPhotosynthetic Processes and MechanismsMitochondrial Function and PathologyMass Spectrometry Techniques and Applications