Sequential C–H activation enabled expedient delivery of polyfunctional arenes
Wensen Ouyang, Xiaoqing Cai, Xiaojian Chen, Jie Wang, Jianhang Rao, Yang Gao, Yanping Huo, Qian Chen, Xianwei Li
Abstract
Modular construction of polyfunctional arenes from abundant feedstocks stands as an unremitting pursue in synthetic chemistry, accelerating the discovery of drugs and materials. Herein, using the multiple C-H activation strategy with versatile imidate esters, the expedient delivery of molecular libraries of densely functionalized sulfur-containing arenes was achieved, which enabled the concise construction of biologically active molecules, such as Bipenamol.
Topics & Concepts
ChemistryCombinatorial chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions