Intrinsic Efficacy of Opioid Ligands and Its Importance for Apparent Bias, Operational Analysis, and Therapeutic Window
Alexander Gillis, Varun Sreenivasan, MacDonald J. Christie
Topics & Concepts
ArrestinFunctional selectivityIntrinsic activityCeiling effectG protein-coupled receptorG proteinOpioidReceptorKnockout mouseSignal transductionChemistryBiologyPharmacologyCell biologyNeuroscienceMedicineGeneticsAgonistPathologyAlternative medicineReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacological Receptor Mechanisms and Effects