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Development of promising acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, in vitro and in silico approaches of pyridine derived fused bis-oxadiazole and bis-thiadiazole derivatives

Rafaqat Hussain, Shoaib Khan, Yousaf Khan, Tayyiaba Iqbal, Saeed Anwar, Tariq Aziz, Metab Alharbi

2024Journal of Molecular Structure16 citationsDOI

Topics & Concepts

ButyrylcholinesteraseChemistryAcetylcholinesterasePyridineOxadiazoleSemicarbazoneIC50StereochemistryProton NMRDocking (animal)AchéIn silicoCarbon-13 NMREnzymeCombinatorial chemistryIn vitroMedicinal chemistryOrganic chemistryBiochemistryNursingGeneMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity
Development of promising acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, in vitro and in silico approaches of pyridine derived fused bis-oxadiazole and bis-thiadiazole derivatives | Litcius