CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques
Maud Mavigner, Laura E. Liao, Alyssa D. Brooks, Ruian Ke, Cameron Mattingly, Nils Schoof, Julia Bergild McBrien, Diane G. Carnathan, Shan Liang, Thomas H. Vanderford, Mirko Paiardini, Deanna A. Kulpa, Jeffrey D. Lifson, Richard M. Dunham, Kirk A. Easley, David M. Margolis, Alan S. Perelson, Guido Silvestri, Ann Chahroudi
Abstract
A favored approach to curing HIV infection aims at inducing viral expression using latency-reversing agents (LRAs) to allow the elimination of infected cells. Here, we tested a combination of two recently identified LRAs, the SMAC mimetic/IAP inhibitor AZD5582, which activates the noncanonical NF-κB pathway, and the antibody (Ab) MT807R1, which depletes CD8α + cells, in SIV-infected rhesus macaques (RMs) on ART.
Topics & Concepts
ViremiaSimian immunodeficiency virusCD8BiologyVirologyLatency (audio)ImmunologyImmune systemCytotoxic T cellVirusLymphocyteIn vivoViral loadAntibodyVirus latencyViral replicationIn vitroGeneticsEngineeringElectrical engineeringHIV Research and TreatmentMosquito-borne diseases and controlCytomegalovirus and herpesvirus research