METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma
Xiangyu Zeng, Fei Zhao, Gaofeng Cui, Yong Zhang, Rajashree A. Deshpande, Yuping Chen, Min Deng, Jake A. Kloeber, Yu Shi, Qin Zhou, Chao Zhang, Jing Hou, Wootae Kim, Xinyi Tu, Yuanliang Yan, Zhijie Xu, Lifeng Chen, Huanyao Gao, Guijie Guo, Jiaqi Liu, Qian Zhu, Yueyu Cao, Jinzhou Huang, Zheming Wu, Shouhai Zhu, Ping Yin, Kuntian Luo, Georges Mer, Tanya T. Paull, Jian Yuan, Kaixiong Tao, Zhenkun Lou
Topics & Concepts
Synthetic lethalityOlaparibPARP1Poly ADP ribose polymeraseRNASmall interfering RNACancer researchGemcitabinePARP inhibitorPolymeraseHomologous recombinationDNA repairDNA damageBiologyDNAExonucleaseRNA interferenceChemistryMolecular biologyCell biologyGeneticsCancerGeneRNA modifications and cancerPARP inhibition in cancer therapyDNA Repair Mechanisms