Recent Advances in Ni-Catalyzed Asymmetric Reductive Difunctionalization of Alkenes

Abstract

Alkenes are cheap and easily available bulk industrial feedstocks.Difunctionalization of alkenes can rapidly construct complex molecules, which have broad applications in organic synthesis.Compared with traditional redox-neutral alkene difunctionalization, the reductive difunctionalization of alkenes can introduce two different electrophiles to both sides of the carbon-carbon double bond, which has the advantages of mild reaction conditions, high functional group tolerance, and no need for pre-prepared organometallic reagents.The latest research progress in nickel-catalyzed reductive difunctionalization of alkenes is summarized.The development prospect of the reaction is prospected.

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