Bifunctional cysteine gold nanoclusters for β-amyloid fibril inhibition and fluorescence imaging: a distinctive approach to manage Alzheimer's disease
A. N. Resmi, C.R. Rekha, M. E. Dhushyandhun, Sarathkumar Elangovan, Sachin J. Shenoy, Kamalesh K. Gulia, Ramapurath S. Jayasree
Abstract
in the BBB model and the AD animal model respectively. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach for AD.
Topics & Concepts
NanoclustersFibrilBiophysicsSenile plaquesAmyloid (mycology)Cerebral amyloid angiopathyChemistryBiocompatibilityIn vivoBiochemistryAlzheimer's diseaseMedicinePathologyDementiaBiologyDiseaseOrganic chemistryInorganic chemistryBiotechnologyNanocluster Synthesis and ApplicationsAlzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding