New prognostic biomarker CMTM3 in low grade glioma and its immune infiltration
Shoubin Li, Peng Gao, Xingliang Dai, Lei Ye, Zhongyong Wang, Hongwei Cheng
Abstract
Background: in the prognosis and immune infiltration of glioma has certain clinical significance. Methods: high and low expression groups. The Tumor Immunity Estimation Resource (TIMER) database was used for immune infiltration analysis. Results: is highly correlated with macrophages (r=0.536, P=1.31e-36), dendritic cells (r=0.546, P=2.85e-38), CD4+ T cells (r=0.517, P=6.17e-34). Conclusions: gene can be used as a potential prognostic marker for WHO grade II and WHO grade III glioma, is related to the immune infiltration in glioma microenvironment, and may became a new immunotherapy target.
Topics & Concepts
GliomaImmune systemSurvival analysisBiologyOncologyLog-rank testMedicineCancer researchInternal medicineImmunologyChemokine receptors and signalingCancer Mechanisms and TherapyImmunotherapy and Immune Responses