Copper-Catalyzed Regioselective Remote C–H Bond Chalcogenation of Aromatic Amine Derivatives without Using Any Large Template
Biprajit Paul, Surajit Das, Indranil Chatterjee
Abstract
-selective chalcogenation of anilide scaffolds via C-H bond functionalization. This methodology employs one of the most earth-abundant and inexpensive Cu(II) catalysts and a commercially available simple aryl chalcogen source without any complex directing template, exogenous ligand, acid/base, oxidant, or other additives. The key feature of this methodology is an impressive regioselectivity along with a wide range of functional group tolerance with good to excellent yields under aerobic conditions.
Topics & Concepts
ChemistryRegioselectivityCatalysisCombinatorial chemistryFunctional groupAmine gas treatingArylChalcogenLigand (biochemistry)CopperSurface modificationMetalAromatic amineMoleculeOrganic chemistryPolymerBiochemistryReceptorAlkylPhysical chemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions