Rationally designed sonocatalyst-enhanced supramolecular ferroptosis inducers for effective cancer therapy
Yida Pang, Yong Luo, Ting Liu, Qian Li, Long‐Can Mei, Junhua Zhang, Chonglu Li, Junrong Li, Yao Sun
Abstract
experiments confirmed that US-activated Ru3 effectively inhibited 4T1 tumor growth with favorable biosafety. This work provides a research framework for the design of next generation ferroptosis inducers.
Topics & Concepts
ChemistryGPX4CytosolBiocompatible materialReactive oxygen speciesCancer cellSupramolecular chemistryInducerCell biologyCatalaseBiochemistryCancer researchBiophysicsPeroxidaseCancer therapyIntracellularLipid peroxidationHydrogen peroxideGlutathioneOxidative stressNanotechnologySignal transductionCell survivalEnzymeProgrammed cell deathPhotothermal therapyConjugateCancerNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRadiopharmaceutical Chemistry and Applications