Patient’s profiling for therapeutic management of inflammatory bowel disease: a tailored approach
Ferdinando D’Amico, Gionata Fiorino, Federica Furfaro, Mariangela Allocca, Giulia Roda, Laura Loy, Alessandra Zilli, Virginia Solitano, Laurent Peyrin‐Biroulet, Silvio Danese
Abstract
Introduction: Several biological drugs and a new small molecule are available for the treatment of Crohn’s disease and ulcerative colitis. However, to date, no reliable predictors of response to treatment have yet been identified.Areas covered: We focused on studies evaluating the therapeutic management of patients with chronic inflammatory bowel diseases in order to identify any predictive factors of response to drugs and to guide therapeutic decisions based on patient and disease characteristics.Expert opinion: The heterogeneity of literature data, the main retrospective nature of the scientific evidence, and the lack of comparative head-to-head trials are the most relevant limitations for identifying factors predicting drug response. In the near future, a personalized approach to patients with chronic inflammatory diseases will be based on patient’s profile to define not only the best drug to use, but also the appropriate follow-up, and the possibility of home care.