Excavating medicinal virtues of chalcones to illuminate a new scope in cancer chemotherapy
T. Nivedya, Nilmadhab Roy, Priyankar Paira, Rinku Chakrabarty
Abstract
anticancer activities of several chalcone-based compounds with strong anticancer potential have been identified, which relies on mechanisms such as cell cycle arrest, regulation of autophagy, and induction of apoptosis. Therefore, researchers have successfully introduced chalcone derivatives to achieve enhanced anticancer activity in traditional chemotherapy. Nevertheless, in-depth research on this highly impactful scaffold is lacking to date. Thus, in this review, we shed light on the recent advances in the relatively unexplored scaffolds of chalcone and its derivatives, which have substantial anticancer activities. Furthermore, future perspectives of the mushrooming research on chalcones as potential anticancer agents (therapeutics) are emphasized.