Native Ambient Mass Spectrometry Imaging of Ligand-Bound and Metal-Bound Proteins in Rat Brain
Emma K. Sisley, Oliver J. Hale, Iain B. Styles, Helen J. Cooper
Abstract
bound. Several natively monomeric proteins displaying distinct spatial distributions were also identified by top-down mass spectrometry. Protein mass spectrometry imaging was achieved at a spatial resolution of 200 μm.
Topics & Concepts
ChemistryMass spectrometryMass spectrometry imagingLigand (biochemistry)Electrospray ionizationCarbonic anhydraseProtein mass spectrometryProtein ligandBiophysicsBiochemistryChromatographyEnzymeReceptorBiologyMass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and ApplicationsMetabolomics and Mass Spectrometry Studies