R-(-)-carvone Attenuated Doxorubicin Induced Cardiotoxicity In Vivo and Potentiated Its Anticancer Toxicity In Vitro
Manal Abbas, Yasser I. Kandil, Manal A. Abbas
Abstract
Background: Doxorubicin is one of the most potent broad-spectrum antitumor and chemotherapeutic agents. However, it produces cardiotoxicity. Aims: . Study Design: Cell culture and animal experiment. Methods: . Furthermore, the mechanism of its cardioprotective effect was studied. Results: was due to an increase in catalase activity. Conclusion: R-(-)-carvone has synergistic anticancer action with doxorubicin on the MCF 7 cell line while decreasing its cardiotoxicity.
Topics & Concepts
DoxorubicinPharmacologyCardiotoxicityIn vivoToxicityCell cultureCarvoneChemistryMedicineBiologyChemotherapyInternal medicineEssential oilLimoneneBiotechnologyGeneticsChromatographyMetal complexes synthesis and propertiesFree Radicals and AntioxidantsBioactive Compounds and Antitumor Agents