Access to 10‐Phenanthrenols <i>via</i> Electrochemical C−H/C−H Arylation
Ruhuai Mei, Chenrui Yang, Feng Xiong, Meihua Mao, Hongmei Li, Junmei Sun, Liang Zou, Wenbo Ma, Lutz Ackermann
Abstract
Abstract A protocol for the synthesis of 10‐phenanthrenol from 1‐biphenyl‐2‐ylethanone bearing an electron‐withdrawing group through metal‐ and oxidant‐free C−H/C−H arylation has been established. The electrochemical intramolecular cycloaromatization avoids the use of excess amounts of chemical oxidizing agents, and provides concise and regio‐selective access to a variety of valuable 10‐phenanthrenol derivatives. magnified image
Topics & Concepts
ChemistryOxidizing agentIntramolecular forceBiphenylElectrochemistryCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryElectrodePhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions