Adapting decarbonylation chemistry for the development of prodrugs capable of <i>in vivo</i> delivery of carbon monoxide utilizing sweeteners as carrier molecules
Ladie Kimberly De La Cruz, Xiaoxiao Yang, Anna Menshikh, Maya Brewer, Wen Lu, Minjia Wang, Siming Wang, Xingyue Ji, Alyssa Cachuela, Haichun Yang, David Gallo, Chalet Tan, Leo E. Otterbein, Mark de Caestecker, Binghe Wang
Abstract
1,2-Dicarbonyl compounds with FDA-approved sweeteners as leaving groups deliver CO for protection against acute kidney injury in mice.
Topics & Concepts
DecarbonylationChemistryCarbon monoxideProdrugIn vivoMoleculeCombinatorial chemistryPharmacologyOrganic chemistryBiochemistryMedicineBiotechnologyCatalysisBiologyHeme Oxygenase-1 and Carbon MonoxideCannabis and Cannabinoid ResearchNeonatal Health and Biochemistry