Hydroxyapatite nanoparticles induced calcium overload-initiated cancer cell-specific apoptosis through inhibition of PMCA and activation of calpain
Xiulin Dong, Chunyu Zang, Yi Sun, Shuiquan Zhang, Changsheng Liu, Jiangchao Qian
Abstract
was released, and caspase-9 and -3 were activated, leading to mitochondrial apoptosis. However, these effects were alleviated by the calpain inhibitor calpeptin, confirming the involvement of calpain in HANP-induced apoptosis. Therefore, our results demonstrated that calcium overload induced by HAPNs caused cancer cell-specific apoptosis by inhibiting PMCA and activating calpain in tumor cells and thus may contribute to a more comprehensive understanding of biological effects of this nanomaterial and facilitate the development of calcium overload cancer therapy.
Topics & Concepts
CalpainApoptosisCalciumCell biologyMaterials scienceCancerCancer cellCancer researchBiophysicsChemistryBiochemistryBiologyInternal medicineMedicineEnzymeMetallurgyCalpain Protease Function and RegulationNerve injury and regenerationSignaling Pathways in Disease