A novel TNFR2 agonist antibody expands highly potent regulatory T cells
Heather Torrey, Willem M. Kühtreiber, Yoshiaki Okubo, Lisa Tran, Katherine Case, Hui Zheng, Éva Scheuring Vanamee, Denise L. Faustman
Abstract
cell expansion was not increased by adding either supplemental TNF ligand or a cross-linking reagent, suggesting that the antibody agonist by itself can elicit maximal activity, a notion that was confirmed by increased secretion of soluble TNFR2. Pending in vivo tests, these features indicate that this TNFR2 antibody agonist has the potential to safely and effectively treat various inflammatory disorders.
Topics & Concepts
AgonistAntibodyCell biologyCytokineReceptorChemistryImmunologyBiologyBiochemistryImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses