Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia
Abolfazl Torabi, Esmaeil Mohammadbagheri, Nader Akbari Dilmaghani, Amir‐Hossein Bayat, Mobina Fathi, Kimia Vakili, Rafieh Alizadeh, Omidvar Rezaeimirghaed, Mohammadreza Hajiesmaeili, Mahtab Ramezani, Leila Simani, Abbas Aliaghaei
Abstract
< 0.05). However, no differences in IL-1β were seen between groups. Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium in patients with COVID-19. This suggests that direct inflammation of the olfactory epithelium could play a role in the acute olfactory loss described in many patients with COVID-19.
Topics & Concepts
AnosmiaProinflammatory cytokineOlfactory epitheliumOlfactory mucosaOlfactionEpitheliumCytokineOlfactory systemTumor necrosis factor alphaRespiratory epitheliumMedicineInflammationImmunologyPathologyCoronavirus disease 2019 (COVID-19)BiologyDiseaseNeuroscienceInfectious disease (medical specialty)PsychiatryOlfactory and Sensory Function StudiesLong-Term Effects of COVID-19Retinal and Optic Conditions