Amentoflavone-loaded nanoparticles enhanced chemotherapy efficacy by inhibition of AKR1B10
Fang Zhao, Yumei Qian, Hongxia Li, Yang Yang, Jing Wang, Weixiong Yu, Min Li, Wei Cheng, Lingling Shan
Abstract
Abstract Therapeutic nanoparticles can be combined with different anticancer drugs to achieve a synergistic therapy and avoid the limitations of traditional medicine and thus have clinical prospects for cancer. Herein, an effective nanoplatform was developed for self-assembling AMF@DOX-Fe 3+ -PEG nanoparticles (ADPF NPs) via the coordination of ferric ions (Fe 3+ ), amentoflavone (AMF), doxorubicin (DOX), and PEG-polyphenol. The ADPF NPs possessed high drug loading efficiency, good stability and dispersion in water, prolonged blood circulation, and pH-dependent release, which leading to targeted drug transport and enhanced drug accumulation in the tumor. The AMF from the ADPF NPs could inhibit the expression of the Aldo-keto reductase family 1B10 (AKR1B10) and nuclear factor-kappa B p65 (NF- κ B p65), which reduced the cardiotoxicity induced by DOX and enhanced the chemotherapy efficacy. This study established a new strategy of combining drug therapy with a nanoplatform. This new strategy has a wide application prospect in clinical tumor therapy.