Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent <i>In Vitro</i> Antiproliferative Activity
Antonino N. Fallica, Valeria Sorrenti, Agata Grazia D’Amico, Loredana Salerno, Giuseppe Romeo, Sebastiano Intagliata, Valeria Consoli, Giuseppe Floresta, Antonio Rescifina, Velia D’Agata, Luca Vanella, Valeria Pittalà
Abstract
can reduce cell invasivity acting through modulation of HO-1 expression.
Topics & Concepts
DU145Heme oxygenaseChemistryPharmacophoreHemeCell growthIn vitroBiochemistryEnzymeK562 cellsPharmacologyCancer researchCancer cellCancerBiologyLNCaPGeneticsHeme Oxygenase-1 and Carbon MonoxideHemoglobin structure and functionEicosanoids and Hypertension Pharmacology