Light-Triggered Catalytic Asymmetric Allylic Benzylation with Photogenerated <i>C</i>-Nucleophiles
Suva Paria, Edoardo Carletti, Michela Marcon, Alessio Cherubini‐Celli, Andrea Mazzanti, Marzio Rancan, Luca Dell’Amico, Marcella Bonchio, Xavier Companyó
Abstract
-nucleophiles. The dual activation of both reaction partners, chiral Lewis-base activation of the electrophile and light activation of the nucleophile, enables the stereoselective installation of benzyl groups at the allylic position to forge tertiary and quaternary carbon centers.
Topics & Concepts
ChemistryNucleophileElectrophileAllylic rearrangementStereoselectivityCatalysisLewis acids and basesMedicinal chemistryStereochemistryOrganic chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques