Remote C(sp<sup>3</sup>)–H functionalization<i>via</i>catalytic cyclometallation: beyond five-membered ring metallacycle intermediates
Mario Martínez‐Mingo, Nuria Rodríguez, Ramón Goméz Arrayás, Juan C. Carretero
Abstract
Despite impressive recent momentum gained in C(sp 3 )–H activation, achieving high regioselectivity in molecules containing different C–H bonds with similar high energy without abusing tailored substitution remains as one of the biggest challenges.
Topics & Concepts
MetallacycleRegioselectivityChemistryRing (chemistry)CatalysisSurface modificationStereochemistryMedicinal chemistryMoleculeBicyclic moleculeOrganic chemistryPhysicsX-ray crystallographyPhysical chemistryDiffractionOpticsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms