A PARP1 PROTAC as a novel strategy against PARP inhibitor resistance via promotion of ferroptosis in p53-positive breast cancer
Ge Li, Shanshan Lin, Zelei Yu, Xinhua Wu, Jingwen Liu, Guihui Tu, Quanyu Liu, Yuan-ling Tang, Qingna Jiang, Jianhua Xu, Qingling Huang, Lixian Wu
Topics & Concepts
PARP1Poly ADP ribose polymeraseCancer researchSynthetic lethalityOlaparibBiologyDrug resistanceBreast cancerPharmacologyCancerDNA repairGeneticsPolymeraseBiochemistryEnzymeGenePARP inhibition in cancer therapyProtein Degradation and InhibitorsCAR-T cell therapy research