Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 Genotype
Teruhiko Yoshida, Khun Zaw Latt, Avi Z. Rosenberg, Shashi Shrivastav, Jurgen Heymann, Marc K. Halushka, Cheryl A. Winkler, Jeffrey B. Kopp
Abstract
The mechanisms in podocytes that mediate the pathologic effects of the APOL1 high-risk (HR) variants remain incompletely understood, although various molecular and cellular mechanisms have been proposed. We previously established conditionally immortalized human urine-derived podocyte-like epithelial cell (HUPEC) lines to investigate APOL1 HR variant-induced podocytopathy.
Topics & Concepts
PodocyteTranscriptomemicroRNABiologyCell biologyGenotypeGene expressionRNAGeneGeneticsKidneyProteinuriaRenal Diseases and GlomerulopathiesRenal and related cancersGenetic and Kidney Cyst Diseases