Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
Reza Nadafi, Catarina Gago de Graça, Eelco D. Keuning, Jasper J. Koning, Sander de Kivit, Tanja Konijn, Sandrine Henri, Jannie Borst, Rogier M. Reijmers, Lisa G. M. van Baarsen, Reina E. Mebius
Abstract
cells and germinal center B cell responses. Our findings uncover the ability of LNSCs to suppress the early activation of autoreactive immune cells and maintain peripheral tolerance.
Topics & Concepts
Lymph node stromal cellStromal cellLymph nodeAntigenCell biologyAntigen-presenting cellBiologyT cellImmunologyChemistryMolecular biologyCancer researchImmune systemT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses