Base-Free Synthesis of Furfurylamines from Biomass Furans Using Ru Pincer Complexes
Danielle L. J. Pinheiro, Martin Nielsen
Abstract
We report the first example of employing homogeneous organometal-catalyzed transfer hydrogenation for the selective reductive amination of furfurals to furfurylamines. An efficient, chemoselective, and base-free method is described using Ru-MACHO-BH as catalyst and iPrOH as H donor. The method tolerates a range of substituents affording moderate to excellent yields.
Topics & Concepts
Reductive aminationPincer movementChemistryBase (topology)CatalysisHomogeneousCombinatorial chemistryAminationTransfer hydrogenationOrganic chemistryRutheniumMathematicsMathematical analysisCombinatoricsAsymmetric Hydrogenation and CatalysisCatalysis for Biomass ConversionNanomaterials for catalytic reactions